PreviousNext

Scientists unravel resistance to breast cancer treatment

// Health | Scientists unravel resistance to breast cancer treatment
Email to a friend Plain text Print version // Font size: Decrease font Enlarge font

By Sola Ogundipe

A research team from the university of Manchester’s Paterson Institute for Cancer Research has identified a molecular flag that will help doctors predict which patients will respond best to complementary hormone therapy with tamoxifen.

The research, funded by the charity Breakthrough Breast Cancer and published in Plos One, looked at the connective tissue surrounding the tumour, which is known to send signals that help the cancer to grow.

The team, part of the Manchester Cancer Research Centre, found that
fibroblast cells — the cells that make up connective tissue in our
bodies -differ in their characteristics from patient to patient and can give clues about tamoxifen treatment response

Tamoxifen — used alongside traditional chemotherapy and radiotherapy
– blocks the female hormone estrogen that, in certain breast cancers, is required by the tumour to grow and it has been shown to improve cancer survival rates by up to one third.

However, about one third of patients with the appropriate type of breast cancer — known as estrogen receptor positive breast cancer –do not respond to tamoxifen or develop resistance to the drug.

Estrogen receptor positive breast cancer is the most common form of
the disease accounting for 70 percent of cases.

When used alongside traditional cancer therapies, Tamoxifen has been shown to be highly effective in some breast cancer patients, but, in a third of cases, the result has not been encouraging.

Scientists hope to predict which patients will respond to tamoxifen,and those who won’t, so the correct treatment is provided instantly which will improve disease outcomes.

They analysed tissue samples from 564 women with invasive breast
cancer, some of whom were given tamoxifen and some who weren’t; this allowed us to make a comparison between treatment responses.

They discovered that women who had low levels of a protein known as
pERK in their cancer-associated fibroblasts did not respond to
tamoxifen. Testing patients for the pERK flag could help doctors
determine whether tamoxifen is an appropriate treatment for their
patient or whether alternative therapies should be explored, so saving time and money.

The researchers now plan to further study molecular flags that are characteristic for cancer-associated fibroblasts.

Understanding how fibroblasts help the tumour to grow will allow the development of new strategies to block their harmful signals and overcome drug resistance.

4 types of breast cancer identified

A comprehensive study has categorized breast cancer into four types, already leading to new ideas on how to treat the different strains.

Scientists are now a step closer to understanding the genetic origins of the four major subtypes of breast cancer.

According to  Nature, the study is part of a project that includes
similar studies of lung and colon cancer.

A consortium of researchers analysed tumours from 825 patients, using six different technologies to examine subsets of the tumours for various defects.

The four main subtypes confirmed by the study are luminal A, luminal B, HER2-enriched and basal-like.

One key finding shows that one of the subtypes is genetically more
similar to ovarian tumours than to other breast cancer tumours.

Patients with that specific mutation, categorized as basal-like, may benefit from the same type of chemotherapy used to treat ovarian cancer, the researchers said.

Cancer patients with luminal A had much better prognoses than those
with luminal B, which could help doctors understand when to treat
patients more aggressively.

And researchers are planning a new clinical trial based on the
findings for HER2 patients, who often — but not always — respond
well to a drug called Herceptin, allowing a more targeted group to get the drug (and others, who may not respond to it, to avoid it).

Comments are moderated. Please keep them clean and brief.

Tagged : No tags for this article

Headlines Newsview all

Latest News: 14 Died In Floods And Building Collapse (Photo)

Torrential rainstorms in the Kenyan capital have left at least 14 people dead, police said Saturday, including at least seven crushed when a six-storey building ... Full story

Nigerian Army Apprehended Tailors Who Made Dresses For Boko Haram Terrorists

Six Boko Haram notorious kingpins were tracked and captured today, Thursday 28th April 2016, by the gallant Nigerian army in a renewed onslaught on the ... Full story

Igbo Youths Threaten Fulani Herdsmen

Following the massacre of no fewer than 40 people of Nimbo community in Uzo-Uwani Local Government Area of Enugu by Fulani herdsmen last Monday, Igbo ...

Fulani Herdsmen Saga: Northern Governors Defend Fulani

The 19 Northern Governors have taken a strong exception to the branding of perpetrators of crimes around the country as Fulani. The Governors, rising from a ...

Oba Of Benin's Death Is A great National Loss Says President Buhari

President Muhammadu Buhari on Friday said he received the news of the passing away of the highly revered traditional ruler of Benin Kingdom, Omo n’Oba ...

See Photo Of Fulani Herdmen And Their Cattle Roaming In Front Of Central Bank Of Nigeria In Abuja

A blog reader sent in this picture, What he said after the cut: These guys really feel they can do what even they feel like doing ...

Transition Monitoring Group Reveals: Jonathan’s Agents Offered Us N2 Billion Ahead of 2015 Elections

The Transition Monitoring Group (TMG) – a coalition of over 400 civic organizations –alleged yesterday that agents of the Jonathan administration offered it a bribe ...

Read How Dog Brought Home A Week Old Baby In A Plastic Bag From A Dumpster

Everyone knows Pui, the heroic dog, in his rural Thailand town, because he saved the life of a premature baby! It was an usual hot day. ...

Enugu Attack: Why Do We Call Attackers Fulani, But Not Kidnappers Igbo Says Governor

– Northern governors have condemned the recent attacks in Agatu and Enugu – The governors however said it was wrong to label the criminals as Fulani – ...

Nigerian Army Plans To Exhume Bodies Of Our Members Buried In A Kaduna Mass Graves Says Shi’ites

The Islamic Movement in Nigeria (IMN), popularly known as Shi’ites, has alleged that the Nigerian Army is planning to exhume bodies of their members allegedly ...

IPOB Cries Out: South East Governors Have Sold The Igbos

The Indigenous People of Biafra, (IPOB) has condemned the South East governors and politicians of trading off Ndigbo course for personal and selfish political interest. The ...

Comment on: Scientists unravel resistance to breast cancer treatment

Rate this article

0

Breaking News

Read Charles Novia Opinion On Tiwa Savage's Revelation

I watched the video interview of Tiwa Savage. And I have a few thoughts on it. Seems to me that the basic idea, coming from a ...

Manchester United Valdez Sent Packing From Standard Liege

Goalkeeper Victor Valdes will return to Manchester United after having his loan deal at Standard Liege terminated. The 34-year-old Spaniard joined Belgian club Standard on loan ...

How Real Madrid’s Medical Team Caused The Injuries Suffered By Ronaldo And Benzema

– Real Madrid’s medical team have been blamed for the club’s injury woes which have affected some of their best players  – Cristiano Ronaldo and Karim Benzema could Madrid’s ...

Is Tiwa Savage Still In Love? I Will Help Teebillz Get Back On His Feet

In spite of the attacks on social media, trauma and emotional ordeal, Tiwa Savage said she is still concerned about her estranged husband Tunji Balogun ...

Unbelievable: Flavour’s Baby Mama Photo Displayed At Abuja Night Club (Photo)

– Flavour’s baby mama Anna Banner’s photo was seen at an Abuja night club – The ex-beauty queen has slammed the club manager – Anna Banner recently ...

Kenya Not Ready To Host CHAN, Given September 2017 Deadline By CAF

Confederation of African Football (CAF) have told Kenya to ensure venues and infrastructure to host the 2018 African Nations Championship (CHAN) is ready by September ...

Odion Ighalo Will Be Sold For The Right Offer Says Nicola Salerno

Watford Sporting Director Nicola Salerno has hinted that Nigeria striker Odion Ighalo could be available for transfer during the summer only if the right offers ...

Totti Meets Passionate Fan With Bizarre Tattoo of Him

A diehard Totti fan, Thomas Jonsson, from Sweden, has met up with Roma legend, Francesco Totti, after the player discovered a body art of him ...

NFF Rejects Redknapp Rumours

The Nigeria Football Federation have debunked rumours that they are interested in hiring former Tottenham manager, Harry Redknapp, as the new Super Eagles handler. British Newspaper ...

Nigeria Interim Coach To Understudy Pep Guardiola At Manchester City

Interim coach of the Super Eagles Salisu Yusuf has declared that travel to England to understudy incoming Manchester City manager Pep Guardiola once he assumes ...