Scientists unravel resistance to breast cancer treatment

// Health | Scientists unravel resistance to breast cancer treatment
Email to a friend Plain text Print version // Font size: Decrease font Enlarge font

By Sola Ogundipe

A research team from the university of Manchester’s Paterson Institute for Cancer Research has identified a molecular flag that will help doctors predict which patients will respond best to complementary hormone therapy with tamoxifen.

The research, funded by the charity Breakthrough Breast Cancer and published in Plos One, looked at the connective tissue surrounding the tumour, which is known to send signals that help the cancer to grow.

The team, part of the Manchester Cancer Research Centre, found that
fibroblast cells — the cells that make up connective tissue in our
bodies -differ in their characteristics from patient to patient and can give clues about tamoxifen treatment response

Tamoxifen — used alongside traditional chemotherapy and radiotherapy
– blocks the female hormone estrogen that, in certain breast cancers, is required by the tumour to grow and it has been shown to improve cancer survival rates by up to one third.

However, about one third of patients with the appropriate type of breast cancer — known as estrogen receptor positive breast cancer –do not respond to tamoxifen or develop resistance to the drug.

Estrogen receptor positive breast cancer is the most common form of
the disease accounting for 70 percent of cases.

When used alongside traditional cancer therapies, Tamoxifen has been shown to be highly effective in some breast cancer patients, but, in a third of cases, the result has not been encouraging.

Scientists hope to predict which patients will respond to tamoxifen,and those who won’t, so the correct treatment is provided instantly which will improve disease outcomes.

They analysed tissue samples from 564 women with invasive breast
cancer, some of whom were given tamoxifen and some who weren’t; this allowed us to make a comparison between treatment responses.

They discovered that women who had low levels of a protein known as
pERK in their cancer-associated fibroblasts did not respond to
tamoxifen. Testing patients for the pERK flag could help doctors
determine whether tamoxifen is an appropriate treatment for their
patient or whether alternative therapies should be explored, so saving time and money.

The researchers now plan to further study molecular flags that are characteristic for cancer-associated fibroblasts.

Understanding how fibroblasts help the tumour to grow will allow the development of new strategies to block their harmful signals and overcome drug resistance.

4 types of breast cancer identified

A comprehensive study has categorized breast cancer into four types, already leading to new ideas on how to treat the different strains.

Scientists are now a step closer to understanding the genetic origins of the four major subtypes of breast cancer.

According to  Nature, the study is part of a project that includes
similar studies of lung and colon cancer.

A consortium of researchers analysed tumours from 825 patients, using six different technologies to examine subsets of the tumours for various defects.

The four main subtypes confirmed by the study are luminal A, luminal B, HER2-enriched and basal-like.

One key finding shows that one of the subtypes is genetically more
similar to ovarian tumours than to other breast cancer tumours.

Patients with that specific mutation, categorized as basal-like, may benefit from the same type of chemotherapy used to treat ovarian cancer, the researchers said.

Cancer patients with luminal A had much better prognoses than those
with luminal B, which could help doctors understand when to treat
patients more aggressively.

And researchers are planning a new clinical trial based on the
findings for HER2 patients, who often — but not always — respond
well to a drug called Herceptin, allowing a more targeted group to get the drug (and others, who may not respond to it, to avoid it).

Comments are moderated. Please keep them clean and brief.

Tagged : No tags for this article

Headlines Newsview all

Zambian labour minister accuses Dangote Cement of bribery

A row is brewing between Zambia and Dangote Cement, a major employer in Africa’s second largest copper producer, after a government minister accused an executive ... Full story

Sixty-seven South Africans died in Synagogue building collapse

Sixty-seven South Africans died in the building collapse that occurred at the Synagogue Church of All Nations in Nigeria, President Jacob Zuma said in a ... Full story

Asari Dokubo: Obasanjo connived with Davies to embarrass Jonathan

In what could apparently be considered a daring move, leader of Niger-Delta Peoples Volunteer Force, NDPVF, Alhaji Dokubo-Asari yesterday exploded, saying that former President Olusegun ...

Synagogue Building Collapse: 45 year old woman walks out of rubbles after being trapped for three days

A woman of about 45 years old walked out of the rubble unaided around 2 a.m. on Tuesday as rescue efforts continued at the site ...

Anita Oyakilome Threatens Her Husband

Following the big breakup of Christ Embassy’s general overseer, Pastor Chris Oyakilome and wife Anita, it seems there is no going back for the once ... Full story

T.B. Joshua says Boko Haram may be responsible for the collapse of the Synagogue building

The founder and General overseer of the Synagogue Church of All Nations, Prophet T. B. Joshua has said Boko Haram may be responsible for the ...

Wole Soyinka - Jonathan knows about Boko Haram financier in CBN

The controversy over alleged sponsors of Boko Haram took a twist yesterday when Nobel Laureate Wole Soyinka said information about a suspected financier of the ...

TB Joshua Claims He Was The Target Of Attack In Church Building That Collapsed

Head of The Synagogue Church of All Nations, Prophet T B Joshua, yesterday declared that the collapse of a section of the church complex, which ...

Nigerian Hackers Rob Bank Of N6.3billion

Nigeria’s Economic and Financial Crimes Commission is on the trail of a group of computer hackers, who have stolen N6.28billion, about $40million, from a new ... Full story

Gunmen Kill Rivers State Governor Amaechi’s Uncle

The people of Ubima in Ikwerre Local Government Area of Rivers State have been thrown into mourning following the murder of Mr. Sabinus Odu, an ...

South African Woman With Ebola Arrested At Murtala Mohammed International Airport

Confusion At Murtala Mohammed International Airport In Ikeja Lagos Over Ebola A woman from South Africa has been arrested by Officials of Lagos State Health Ministry ... Full story

Comment on: Scientists unravel resistance to breast cancer treatment

Rate this article

0

Featured author

Paula Obiewkwe

Breaking News

Korede Bello Grabs Another Award

Fast-rising singer, Korede Bello last weekend walked away with an award at the PNA 2014, which was held at Sheraton Hotel, Lagos Nigeria.Korede Bello, who ...

Top Model, Doyin Haastrup Gets Baby Boy

Top model, Doyin Haastrup Olatokunbo is presently one of the happiest women in the world. The respected lady has welcomed a bundle of joy into ...

Osas Ighodaro Shows Off Sexy Shape In Swim Wear

Tinsel star, Osas Ighodaro, is leaving no stone unturned as she aims to remain relevant in the showbiz industry. She is taking every opportunity to ...

People are Flattering Me About My Looks……….Omawunmi

Singer Omawunmi who recently got engaged, is however looking radiant as the day goes by.The singer who has been admired and adored by many, is ...

What You Must Know About Nigerian Musicians

Do you know that most of our popular nigerian musicians bear interestingly funny names? Little wonder most of them bear their stage names or coin ...

How Hoodlums Attacked Actress Nkiru Kiki Omeili

Popular Tinsel actress, Nkiru Kiki Omeili recently narrated her ordeal in the hands of hoodlums who broke into her car and removed valuable parts.Omeili is ...

Several Nigerian Stars Endorse Juliet Ibrahim Foundation (Photos)

The Juliet Ibrahim Foundation (JIF) has received a massive boost with top Nigerian showbiz stars identifying with it. Many prominent figures in the entertainment circle ...

Entries Open For Yoruba Movies Academy Awards As Event Holds Nov. 30

Organisers of the prestigious Yoruba Movies AcademyAwards (YMAA) have called for entries for the 2014 edition of the awards.A statement obtained by Nigeriafilms.com quoted the ...

I’m Enjoying Marriage—Dr Sid

Mavin Records music artiste, Dr. Sid, who had an elaborate wedding in August 2014, has expressed his joy of being married to his wife, Simi ...

Omotola In America For ‘Blood In The Lagoon’

Mother of four superstar actress, Omotola Jalade-Ekeinde is currently in the US to promote her new flick, ‘Blood In The Lagoon’, directed by Teco Benson.The ...