Victoria Azarenka has withdrawn from Wimbledon before her second round match with a knee injury.
The Belarusian, a two-time semi-finalist at SW19, fell heavily in her opening match against Maria Joao Koehler before going through 6-1 6-2.
However, she required a medical time-out at the start of the second set on Monday and had to have the knee strapped.
She was due to be first up on Centre Court against Flavia Pennetta on Wednesday but pulled out just minutes before the match.
The news is a huge blow to Azarenka and indeed the women's draw, with few live dangers to five-time champion and hot favourite, Serena Williams, remaining in the draw.
Pennetta will face Alize Cornet in the third round after the Frenchwoman defeat Su-Weh Hsieh 6-3 6-2.